Towards a Functional Understanding of Protein N-Terminal Acetylation
Open Access
- 31 May 2011
- journal article
- primer
- Published by Public Library of Science (PLoS) in PLoS Biology
- Vol. 9 (5), e1001074
- https://doi.org/10.1371/journal.pbio.1001074
Abstract
Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein–protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come.Keywords
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