Gold Nanoparticles for Biology and Medicine
- 20 April 2010
- journal article
- review article
- Published by Wiley in Angewandte Chemie
- Vol. 49 (19), 3280-3294
- https://doi.org/10.1002/anie.200904359
Abstract
Gold colloids have fascinated scientists for over a century and are now heavily utilized in chemistry, biology, engineering, and medicine. Today these materials can be synthesized reproducibly, modified with seemingly limitless chemical functional groups, and, in certain cases, characterized with atomic‐level precision. This Review highlights recent advances in the synthesis, bioconjugation, and cellular uses of gold nanoconjugates. There are now many examples of highly sensitive and selective assays based upon gold nanoconjugates. In recent years, focus has turned to therapeutic possibilities for such materials. Structures which behave as gene‐regulating agents, drug carriers, imaging agents, and photoresponsive therapeutics have been developed and studied in the context of cells and many debilitating diseases. These structures are not simply chosen as alternatives to molecule‐based systems, but rather for their new physical and chemical properties, which confer substantive advantages in cellular and medical applications.Keywords
This publication has 127 references indexed in Scilit:
- Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) WarheadsJournal of the American Chemical Society, 2009
- Gene Regulation with Polyvalent siRNA−Nanoparticle ConjugatesJournal of the American Chemical Society, 2009
- Templated Spherical High Density Lipoprotein NanoparticlesJournal of the American Chemical Society, 2009
- Entrapment of Hydrophobic Drugs in Nanoparticle Monolayers with Efficient Release into Cancer CellsJournal of the American Chemical Society, 2009
- Aptamer-Targeted Gold Nanoparticles As Molecular-Specific Contrast Agents for Reflectance ImagingBioconjugate Chemistry, 2008
- Inhibition of HIV Fusion with Multivalent Gold NanoparticlesJournal of the American Chemical Society, 2008
- Nano-Flares: Probes for Transfection and mRNA Detection in Living CellsJournal of the American Chemical Society, 2007
- Controlling the Cellular Uptake of Gold NanorodsLangmuir, 2007
- Maximizing DNA Loading on a Range of Gold Nanoparticle SizesAnalytical Chemistry, 2006
- What Controls the Melting Properties of DNA-Linked Gold Nanoparticle Assemblies?Journal of the American Chemical Society, 2003