Immunological Functions of Steryl Glycosides
- 31 August 2012
- journal article
- review article
- Published by Walter de Gruyter GmbH in Archivum Immunologiae et Therapiae Experimentalis
- Vol. 60 (5), 351-359
- https://doi.org/10.1007/s00005-012-0190-1
Abstract
Steryl glycosides, sterols glycosylated at the 3β-hydroxy group, have been widely found in plants, algae, and fungi, but are rare in bacteria and animals. Glycosylation of sterols is known to modify properties of the cell membrane and confer resistance against stresses by freezing or heat-shock on cells. Furthermore, accumulating evidence obtained from recent research suggests important biological functions of steryl glycosides, including regulation of host defenses against pathogens, lipid metabolism, and developmental events. This review is focused on the immunological functions of steryl glycosides, such as modulation of host immune functions upon exposure to cholesteryl glycosides produced by pathogenic bacteria.Keywords
This publication has 61 references indexed in Scilit:
- Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signalsNature Immunology, 2011
- Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infectionThe Journal of Experimental Medicine, 2011
- Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivityJCI Insight, 2011
- Membrane-associated Activation of Cholesterol α-Glucosyltransferase, an Enzyme Responsible for Biosynthesis of Cholesteryl-α-d-Glucopyranoside in Helicobacter pylori Critical for Its SurvivalJournal of Histochemistry & Cytochemistry, 2011
- Acylated Cholesteryl Galactosides Are Specific Antigens of Borrelia Causing Lyme Disease and Frequently Induce Antibodies in Late Stages of DiseasePublished by Elsevier BV ,2009
- Role of Peyer's patches in the induction of Helicobacter pylori -induced gastritisProceedings of the National Academy of Sciences of the United States of America, 2007
- An African origin for the intimate association between humans and Helicobacter pyloriNature, 2007
- Helicobacter pylori-Specific CD4+T Cells Home to and Accumulate in the HumanHelicobacter pylori-Infected Gastric MucosaInfection and Immunity, 2005
- Helicobacter pylori and gastrointestinal tract adenocarcinomasNature Reviews Cancer, 2002
- Helicobacter pyloriInfection and the Development of Gastric CancerNew England Journal of Medicine, 2001