Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection
Open Access
- 9 May 2011
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 208 (6), 1163-1177
- https://doi.org/10.1084/jem.20102555
Abstract
TLR-mediated signaling and the production of IL-12 by APCs, rather than recognition of microbial antigens, enables rapid iNKT cell responses to diverse microbial infections.Keywords
This publication has 51 references indexed in Scilit:
- Antimicrobial activity of mucosal-associated invariant T cellsNature Immunology, 2010
- Rapid and reliable generation of invariant natural killer T-cell linesin vitroImmunology, 2009
- Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramideBioorganic & Medicinal Chemistry Letters, 2009
- NKT cells prevent chronic joint inflammation after infection withBorrelia burgdorferiProceedings of the National Academy of Sciences of the United States of America, 2008
- The Immunological Genome Project: networks of gene expression in immune cellsNature Immunology, 2008
- NK Cell–Like Behavior of Vα14i NK T Cells during MCMV InfectionPLoS Pathogens, 2008
- Liver Autoimmunity Triggered by Microbial Activation of Natural Killer T CellsCell Host & Microbe, 2008
- Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activationProceedings of the National Academy of Sciences of the United States of America, 2007
- Mechanism of CD1d-restricted natural killer T cell activation during microbial infectionNature Immunology, 2003
- CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lungNature Medicine, 2002