Sequence and expression of a metabotropic glutamate receptor
- 1 February 1991
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 349 (6312), 760-765
- https://doi.org/10.1038/349760a0
Abstract
The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.This publication has 31 references indexed in Scilit:
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