Coronaviruses in the Limelight
Open Access
- 15 February 2005
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 191 (4), 489-491
- https://doi.org/10.1086/428510
Abstract
For ∼ years after their first description by Tyrrell and Byneo in 1965 [1], the field of human coronaviruses (HCoVs) was pretty dull. There were classic early descriptions of their respiratory pathogenicity in volunteer studies [2, 3], and there were seroepidemiologic studies of the 2 most easily studied strains, HCoV-229E and HCoV-OC43 [4–6]. Efforts to implicate HCoVs in diseases of the gastrointestinal tract were largely unsuccessful, with the possible exception of a postulated role in necrotizing enterocolitis of newborns [7]. During this time, the fields of animal CoVs and of the molecular biology of CoVs were, in contrast, buzzing. CoVs were discovered in large numbers and were implicated in a rich variety of animal diseases in multiple species. Diseases as widely varying as progressive peritonitis, nephritis, acute and chronic hepatitis, and subacute encephalitis were described, along with the more traditional respiratory and gastrointestinal syndromes, and pathogenesis was explained through broad mixtures of viral cytopathogenicity, immunologic damage, and genetic susceptibilities. The CoV genome proved to be the largest of all of the RNA viruses and to have a unique strategy of replication, with transcription and protein production occurring through a nested set of mRNA molecules [8].Keywords
This publication has 30 references indexed in Scilit:
- Detection of Antigen in Bronchial Epithelium and Macrophages in Acute Kawasaki Disease by Use of Synthetic AntibodyThe Journal of Infectious Diseases, 2004
- Kawasaki syndromeThe Lancet, 2004
- Identification of a new human coronavirusNature Medicine, 2004
- Cutting Edge: CD8 T Cell-Mediated Demyelination Is IFN-γ Dependent in Mice Infected with a Neurotropic CoronavirusThe Journal of Immunology, 2002
- Oligoclonal IgA Response in the Vascular Wall in Acute Kawasaki DiseaseThe Journal of Immunology, 2001
- IgA Plasma Cell Infiltration of Proximal Respiratory Tract, Pancreas, Kidney, and Coronary Artery in Acute Kawasaki DiseaseThe Journal of Infectious Diseases, 2000
- Detection of human coronavirus 229E in nasal washings using RNA:RNA hybridizationJournal of Medical Virology, 1989
- Association of Coronavirus Infection with Neonatal Necrotizing EnterocolitisPEDIATRICS, 1982
- SEROEPIDEMIOLOGIC STUDIES OF CORONAVIRUS INFECTION IN ADULTS AND CHILDREN1American Journal of Epidemiology, 1970
- Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease.Proceedings of the National Academy of Sciences of the United States of America, 1967