CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response
Open Access
- 5 April 2010
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 189 (1), 23-39
- https://doi.org/10.1083/jcb.200912163
Abstract
Two domains of centrosomal protein CDK5RAP2, CNN1 and CNN2, link centrosomes to mitotic spindle poles. CNN1 lacking centrosomes are unable to recruit pericentriolar matrix components that mediate attachment to spindle poles.Keywords
This publication has 71 references indexed in Scilit:
- Asymmetric centrosome inheritance maintains neural progenitors in the neocortexNature, 2009
- Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formationThe EMBO Journal, 2009
- Centrocortin Cooperates with Centrosomin to Organize Drosophila Embryonic Cleavage FurrowsCurrent Biology, 2009
- Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130The EMBO Journal, 2009
- DNA repair deficiency and neurological diseaseNature Reviews Neuroscience, 2009
- A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain sizeNature Genetics, 2005
- Proteomic characterization of the human centrosome by protein correlation profilingNature, 2003
- The PACT domain, a conserved centrosomal targeting motif in the coiled‐coil proteins AKAP450 and pericentrinEMBO Reports, 2000
- A Complex of NuMA and Cytoplasmic Dynein Is Essential for Mitotic Spindle AssemblyCell, 1996
- Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extractsNature, 1996