Influence on Hazelnut Oil Administration on Peroxidation Status of Erythrocytes and Apolipoprotein B 100-Containing Lipoproteins in Rabbits Fed on a High Cholesterol Diet
- 15 May 2003
- journal article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 51 (13), 3905-3909
- https://doi.org/10.1021/jf0300238
Abstract
Hazelnut oil (HO) is rich in monounsaturated fatty acids (MUFA). The effect of a high cholesterol (HC) diet with and without HO on lipids and lipid peroxide levels in plasma, apolipoprotein B 100-containing lipoproteins (VLDL + LDL), and erythrocytes as well as hematological data was investigated in rabbits. A HC diet caused significant increases in lipid peroxide levels in plasma and apo B-containing lipoproteins together with histopathological atherosclerotic findings in aorta. In addition, this diet resulted in hemolytic anemia associated with increased endogenous diene conjugate (DC) levels, but H2O2-induced malondialdehyde (MDA) levels remained unchanged in erythrocytes. HO supplementation reduced lipid peroxide levels in plasma and apolipoprotein B 100-containing lipoproteins as well as aortic atherosclerotic lesions in rabbits fed an HC diet without any decreasing effect on lipid levels. In addition, HO was found to reduce hemolytic anemia together with significant decreases in DC and H2O2-induced MDA levels. Keywords: Hazelnut oil; high cholesterol diet; lipid peroxidation; erythrocytes; apo B-containing lipoproteins; rabbitThis publication has 21 references indexed in Scilit:
- Effect of ingestion of virgin olive oil on human low-density lipoprotein compositionEuropean Journal of Clinical Nutrition, 2002
- A Review on Grain and Nut Deterioration and Design of the Dryers for Safe Storage with Special Reference to Turkish HazelnutsCritical Reviews in Food Science and Nutrition, 2001
- β-VLDL Hypercholesterolemia Relative to LDL Hypercholesterolemia Is Associated With Higher Levels of Oxidized Lipoproteins and a More Rapid Progression of Coronary Atherosclerosis in RabbitsArteriosclerosis, Thrombosis, and Vascular Biology, 1997
- High cholesterol diet supplemented with sunflower seed oil but not olive oil stimulates lipid peroxidation in plasma, liver, and aorta of ratsThe Journal of Nutritional Biochemistry, 1995
- Dietary fish oil enhances plasma and LDL oxidative modification in ratsThe Journal of Nutritional Biochemistry, 1995
- A rapid and simple method for measuring the susceptibility of low-density-lipoprotein and very-low-density-lipoprotein to copper-catalyzed oxidationClinica Chimica Acta; International Journal of Clinical Chemistry, 1994
- Lipid peroxidation in liver microsomes of rats fed soybean, olive, and coconut oilThe Journal of Nutritional Biochemistry, 1993
- The role of lipid peroxidation and antioxidants in oxidative modification of LDLFree Radical Biology & Medicine, 1992
- Medical Education: Past, Present and FutureThe New England Journal of Medicine, 1977
- The Susceptibility to Autoxidation of Human Red Cell Lipids in Health and DiseaseBritish Journal of Haematology, 1972