Dietary fat’gene interactions in cancer
Open Access
- 12 September 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cancer and Metastasis Reviews
- Vol. 26 (3-4), 535-551
- https://doi.org/10.1007/s10555-007-9075-x
Abstract
Epidemiologic studies have suggested for decades an association between dietary fat and cancer risk. A large body of work performed in tissue culture and xenograft models of cancer supports an important role of various types of fat in modulating the cancer phenotype. Yet, the molecular mechanisms underlining the effects of fat on cancer initiation and progression are largely unknown. The relationships between saturated fat, polyunsaturated fat, cholesterol or phytanic acid with cancer have been reviewed respectively. However, few have considered the relationship between all of these fats and cancer. The purpose of this review is to present a more cohesive view of dietary fat’gene interactions, and outline a working hypothesis of the intricate connection between fat, genes and cancer.Keywords
This publication has 196 references indexed in Scilit:
- Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1cBiochemical Journal, 2007
- Use of analogs and inhibitors to study the functional significance of protein palmitoylationMethods, 2006
- Therapeutic intervention based on protein prenylation and associated modificationsNature Chemical Biology, 2006
- Nuclear factor-κB in cancer development and progressionNature, 2006
- Resolution of inflammation: the beginning programs the endNature Immunology, 2005
- Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cellsOncogene, 2005
- Serum levels of phytanic acid are associated with prostate cancer riskThe Prostate, 2005
- The history of cancer epigeneticsNature Reviews Cancer, 2004
- Inflammation and cancerNature, 2002
- Reacylation of platelet activating factor with eicosapentaenoic acid in fish-oil-enriched monkey neutrophilsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987