Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling
- 1 January 2011
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry
- Vol. 19 (1), 504-512
- https://doi.org/10.1016/j.bmc.2010.11.002
Abstract
No abstract availableKeywords
Funding Information
- NIH (DA27081, DA16604, DA15175)
This publication has 47 references indexed in Scilit:
- Management of attention-deficit hyperactivity disorder in adults: focus on methylphenidate hydrochlorideNeuropsychiatric Disease and Treatment, 2009
- A novel photoaffinity ligand for the dopamine transporter based on pyrovaleroneBioorganic & Medicinal Chemistry, 2009
- The binding sites for cocaine and dopamine in the dopamine transporter overlapNature Neuroscience, 2008
- Asymmetric Synthesis and Pharmacology of Methylphenidate and Its Para-Substituted DerivativesJournal of Medicinal Chemistry, 1998
- A novel photoaffinity label for the dopamine transporter based on N-substituted 3α-[bis(4′-fluorophenyl)methoxy]tropaneBioorganic & Medicinal Chemistry Letters, 1997
- Neurobiology of cocaine abuseTrends in Pharmacological Sciences, 1992
- Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporterJournal of Medicinal Chemistry, 1992
- Photoaffinity labeling of the mammalian dopamine transporterFEBS Letters, 1989
- Rapid chromatographic technique for preparative separations with moderate resolutionThe Journal of Organic Chemistry, 1978
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973