Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats
- 30 April 2012
- journal article
- Published by Medknow in Asian Pacific Journal of Tropical Biomedicine
- Vol. 2 (4), 281-286
- https://doi.org/10.1016/s2221-1691(12)60023-9
Abstract
To investigate the antidiabetic property of Merremia emarginata (M. emarginata) Burm. F. plant in streptozotocin induced diabetic rats. The dose dependent effects of 28 days oral treatment with methanol extract (100, 200 and 400 mg/kg) from the plant of M. emarginata on blood glucose level, body weight, insulin, total hemoglobin, glycosylated haemoglobin (HbA1C), total protein, serum urea, serum creatinine and carbohydrate metabolizing enzymes were evaluated in streptozotocin induced diabetic rats. Histology of pancreas was also studied. A significant decrease in blood glucose, serum urea and serum creatinine and significant increase in body weight, insulin and protein level were observed in diabetic rats treated with M. emarginata. Treatment with M. emarginata resulted in a significant reduction of HbA1C and an increase in total hemoglobin level. The activities of carbohydrate metabolizing enzymes such as hexokinase were significantly increased whereas glucose-6-phosphatase, fructose-1, 6-bisphosphatase were significantly decreased by the administration of M. emarginata in diabetic rats. Histology of diabetic rats treated with M. emarginata showed the pancreatic β-cells regeneration. These findings suggest that M. emarginata has potent antidiabetic activity in streptozotocin induced diabetic rats.Keywords
This publication has 37 references indexed in Scilit:
- Antidiabetic activity of methanolic bark extract of Albizia odoratissima Benth. in alloxan induced diabetic albino miceAsian Pacific Journal of Tropical Medicine, 2011
- Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin–nicotinamide induced type 2 diabetic ratsAsian Pacific Journal of Tropical Medicine, 2011
- Antioxidant and antipyretic studies on Pothos scandens LAsian Pacific Journal of Tropical Medicine, 2011
- Antidiabetic activity of aqueous fruit extract of Cucumis trigonus Roxb. in streptozotocin-induced-diabetic ratsJournal of Ethnopharmacology, 2010
- Aldose reductase: A novel therapeutic target for inflammatory pathologiesThe International Journal of Biochemistry & Cell Biology, 2010
- Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.)BMC Complementary and Alternative Medicine, 2009
- Antidiabetic activity of Diospyros peregrina fruit: Effect on hyperglycemia, hyperlipidemia and augmented oxidative stress in experimental type 2 diabetesFood and Chemical Toxicology, 2009
- Normo-glycemic and hypolipidemic effect of costunolide isolated from Costus speciosus (Koen ex. Retz.)Sm. in streptozotocin-induced diabetic ratsChemico-Biological Interactions, 2009
- Phenotypic Type 2 Diabetes in Obese YouthDiabetes, 2009
- An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extractBMC Complementary and Alternative Medicine, 2007