Antidiabetic activity of methanolic bark extract of Albizia odoratissima Benth. in alloxan induced diabetic albino mice

Abstract

To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth. bark in alloxan induced diabetic mice. Group-I(normal control) mice received only basal diet without any treatment. In Group– II(Diabetic control) mice, diabetes was induced by alloxan (150 mg/kg i.p.) and received only Tween 80, 5% v/v in normal saline. Group– III and Group– IV mice received metformin (10mg/kg) and gliclazide (10 mg/kg) as standard drugs. Group– V and VI mice received methanolic bark extract of Albizia odoratissimaat doses of 250 and 500 mg/kg body weight p.o., respectively. The results of the study indicates that Albizia odoratissima bark extract significantly (PAlbizia odoratissima has protective effects on the protection of vital tissues (pancreas, kidney, liver, heart and spleen), thereby reducing the causation of diabetes in experimental animals.