Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models
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- 1 September 2013
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 73 (17), 5315-5319
- https://doi.org/10.1158/0008-5472.can-13-1069
Abstract
Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with cancer. In addition, these models can be used to study metastasis and tumor genetic evolution. This review examines the development, challenges, and broad use of these attractive preclinical models. Cancer Res; 73(17); 5315–9. ©2013 AACR.Keywords
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