Extranodal NK/T‐cell lymphoma: diagnosis and treatment cues
Open Access
- 19 February 2008
- journal article
- review article
- Published by Wiley in Hematological Oncology
- Vol. 26 (2), 66-72
- https://doi.org/10.1002/hon.847
Abstract
Extranodal NK/T‐cell lymphoma, nasal type (ENKL) is mostly endemic to East Asia. It predominantly occurs in the nasal or paranasal areas and less frequently in the skin. Most of the tumours show NK‐cell, but rarely T‐cell, phenotypes. The Epstein–Barr virus (EBV) genome can be usually detected in lymphoma cells. Geographic localization of ENKL matches the endemic distribution of EBV, suggesting that EBV plays an important role in lymphomagenesis. Originally, NK‐cell and T‐cell types were believed to present the same clinicopathologic characteristics, but recent data suggest more aggressive characteristics for the NK‐cell phenotype. Although ENKL is sensitive to radiotherapy, it shows a poorer response to chemotherapeutic agents than other lymphomas due to expression of p‐glycoprotein. Therefore, new therapeutic approaches must be considered. Several new clinical trials are now being conducted in East Asia. Copyright © 2008 John Wiley & Sons, Ltd.This publication has 68 references indexed in Scilit:
- Phase I study of dexamethasone, methotrexate, ifosfamide, l‐asparaginase, and etoposide (SMILE) chemotherapy for advanced‐stage, relapsed or refractory extranodal natural killer (NK)/T‐cell lymphoma and leukemiaCancer Science, 2008
- Effect of Positive Bone Marrow EBV In situ Hybridization in Staging and Survival of Localized Extranodal Natural Killer/T-Cell Lymphoma, Nasal-TypeClinical Cancer Research, 2007
- Hematopoietic stem cell transplantation for natural killer-cell lineage neoplasmsBone Marrow Transplantation, 2006
- Blastic natural killer cell lymphoma/leukemia (CD56‐positive blastic tumor)Cancer, 2005
- Leukemia and Lymphoma of Natural Killer CellsJournal of Clinical and Experimental Hematopathology, 2005
- The best way to use asparaginase in childhood acute lymphatic leukaemia – still to be defined?British Journal of Haematology, 2004
- Bone Marrow Involvement by Nasal NK Cell Lymphoma at Diagnosis Is UncommonAmerican Journal of Clinical Pathology, 2001
- Lymphoma of the nasal cavity and paranasal sinusesCancer, 1997
- CD56+ NK lymphomas:clinicopathological features and prognosisBritish Journal of Haematology, 1997
- Characteristics and uses of natural killer cellsImmunology Today, 1988