Hematopoietic stem cell transplantation for natural killer-cell lineage neoplasms
Open Access
- 9 January 2006
- journal article
- research article
- Published by Springer Science and Business Media LLC in Bone Marrow Transplantation
- Vol. 37 (4), 425-431
- https://doi.org/10.1038/sj.bmt.1705244
Abstract
Neoplasms of natural killer (NK)-lineage are rare. Their prognosis is generally poor except for cases of solitary nasal NK-cell lymphoma. The NK-cell Tumor Study Group performed a survey in Japan on patients diagnosed between 1994 and 1998. Of 228 patients selected for analysis, 40 underwent HSCT (15 allografts and 25 autografts). The underlying diseases were myeloid/NK cell precursor acute leukemia (n=4), blastic NK-cell lymphoma (n=11), aggressive NK-cell leukemia (n=3), and nasal-type extranodal NK-cell lymphoma (n=22). At the time of HSCT, 22 patients were in complete remission (CR), 11 were in relapse, and seven were primary refractory. All patients received myeloablative conditioning regimens including total-body irradiation. Sixteen died of disease progression, and six of treatment-related causes. Overall, 4-year survival was 39% with a median follow-up of 50 months; this was significantly better than that of patients who did not undergo HSCT (21%, P=0.0003). For patients transplanted in CR, the 4-year overall survival was 68%, which was significantly better than that of patients who went into CR but did not undergo HSCT (P=0.03). These findings suggest that the HSCT is a promising treatment strategy for NK-cell lineage.Keywords
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