A short review: Recent advances in electrospinning for bone tissue regeneration
Open Access
- 1 January 2012
- journal article
- Published by SAGE Publications in Journal of Tissue Engineering
- Vol. 3 (1)
- https://doi.org/10.1177/2041731412443530
Abstract
Nanofibrous structures developed by electrospinning technology provide attractive extracellular matrix conditions for the anchorage, migration, and differentiation of tissue cells, including those responsible for the regeneration of hard tissues. Together with the ease of set up and cost-effectiveness, the possibility to produce nanofibers with a wide range of compositions and morphologies is the merit of electrospinning. Significant efforts have exploited the development of bone regenerative nanofibers, which includes tailoring of composite/hybrid compositions that are bone mimicking and the surface functionalization such as mineralization. Moreover, by utilizing bioactive molecules such as adhesive proteins, growth factors, and chemical drugs, in concert with the nanofibrous matrices, it is possible to provide artificial materials with improved cellular responses and therapeutic efficacy. These studies have mainly focused on the regulation of stem cell behaviors for use in regenerative medicine and tissue engineering. While there are some challenges in achieving controllable delivery of bioactive molecules and complex-shaped three-dimensional scaffolds for tissue engineering, the electrospun nanofibrous matrices can still have a beneficial impact in the area of hard-tissue regeneration.Keywords
This publication has 68 references indexed in Scilit:
- The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix AnaloguesPolymers, 2010
- Direct coating of bioactive sol–gel derived silica on poly(ε-caprolactone) nanofibrous scaffold using co-electrospinningMaterials Letters, 2010
- Hydroxyapatite nucleation and growth mechanism on electrospun fibers functionalized with different chemical groups and their combinationsBiomaterials, 2010
- Composite nanofiber of bioactive glass nanofiller incorporated poly(lactic acid) for bone regenerationMaterials Letters, 2010
- Electrospun antimicrobial polyurethane nanofibers containing silver nanoparticles for biotechnological applicationsMacromolecular Research, 2009
- Biomimetic materials for tissue engineeringAdvanced Drug Delivery Reviews, 2008
- Patterning of Electrospun Fibers Using Electroconductive TemplatesAdvanced Materials, 2007
- Bioactive and degradable hybridized nanofibers of gelatin–siloxane for bone regenerationJournal of Biomedical Materials Research Part A, 2007
- In situ growth of hydroxyapatite within electrospun poly(DL‐lactide) fibersJournal of Biomedical Materials Research Part A, 2007
- Nanofiber generation of hydroxyapatite and fluor‐hydroxyapatite bioceramicsJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2005