MicroRNAs: Game Changers in the Regulation ofα-Synuclein in Parkinson’s Disease
Open Access
- 2 May 2019
- journal article
- review article
- Published by Hindawi Limited in Parkinson's Disease
- Vol. 2019, 1-10
- https://doi.org/10.1155/2019/1743183
Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Its neuropathological hallmarks include neuronal loss in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies containing aggregates of α-synuclein (α-syn). An imbalance between the rates of α-syn synthesis, aggregation, and clearance can result in abnormal α-syn levels and contribute to the pathogenesis of PD. MicroRNAs (miRNAs) are endogenous single-stranded noncoding RNAs (∼22 nucleotides) that have recently emerged as key posttranscriptional regulators of gene expression. In this review, we summarize the functions of miRNAs that directly target α-syn. We also review miRNAs that indirectly impact α-syn levels or toxicity through different pathways, including those involved in the clearance of α-syn and neuroinflammation.Keywords
Funding Information
- National Natural Science Foundation of China (81800174)
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