Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and Microbial Eradication in Complicated Urinary Tract Infection

Abstract

Spread of beta-lactamase enzymes among gram-negative pathogens threatens the usefulness of many beta-lactam antibiotics and has resulted in greater reliance on carbapenems.^1,2 Dissemination of carbapenemases (eg, Klebsiella pneumoniae carbapenemase) in Enterobacteriaceae worldwide is identified as an urgent threat by the Centers for Disease Control and Prevention, and the World Health Organization has identified development of new agents as a critical need.^3-5 Quiz Ref ID Infections due to carbapenem-resistant Enterobacteriaceae are most often urinary tract infections (UTIs), including acute pyelonephritis,⁶ and are usually health care–associated.^7,8 Mortality attributable to carbapenem-resistant Enterobacteriaceae infections is 20% to 54.3%^6,9-11 and reflects the need for better treatment options.