Hepatitis C virus micro-elimination: Where do we stand?
Open Access
- 28 April 2021
- journal article
- review article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 27 (16), 1728-1737
- https://doi.org/10.3748/wjg.v27.i16.1728
Abstract
Hepatitis C virus (HCV) elimination by 2030, using direct-acting antiviral treatments, has been promoted by the World Health Organization. This achievement is not attainable, however, particularly after the 2020 pandemic of the coronavirus disease 2019. Consequently, the more realistic objective of eliminating HCV from population segments for which targeted strategies of prevention and treatment are easily attained has been promoted in Europe, as a valid alternative. The underlying idea is that micro-elimination will ultimately lead to macro-elimination. The micro-elimination strategy may target different specific populations and at-risk groups. Different settings, including prisons and hospitals, have also been identified as micro-elimination scenarios. In addition, dedicated micro-elimination strategies have been designed that are tailored at the geographical level according to HCV epidemiology and individual country’s income. The main elements of a valid and successful micro-elimination project are reliable epidemiological data and active involvement of all the stakeholders. Community involvement represents another essential component for a successful program.Keywords
This publication has 34 references indexed in Scilit:
- EASL recommendations on treatment of hepatitis C: Final update of the series☆Journal of Hepatology, 2020
- Impact of COVID-19 on global HCV elimination effortsJournal of Hepatology, 2020
- The impact of COVID-19 on hepatitis eliminationThe Lancet Gastroenterology & Hepatology, 2020
- Global timing of hepatitis C virus elimination in high‐income countriesLiver International, 2019
- What Is Needed to Eliminate Hepatitis B Virus and Hepatitis C Virus as Global Health ThreatsGastroenterology, 2019
- The Micro-Elimination Approach to Eliminating Hepatitis C: Strategic and Operational ConsiderationsSeminars in Liver Disease, 2018
- Micro-elimination – A path to global elimination of hepatitis CJournal of Hepatology, 2017
- Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling studyThe Lancet Gastroenterology & Hepatology, 2016
- The prevalence of hepatitis C virus infection in Egypt 2015: implications for future policy on prevention and treatmentLiver International, 2016
- Models of Care for the Management of Hepatitis C Virus Among People Who Inject Drugs: One Size Does Not Fit AllClinical Infectious Diseases, 2013