Asymmetric Organocatalytic Biginelli Reactions: A New Approach To Quickly Access Optically Active 3,4‐Dihydropyrimidin‐2‐(1H)‐ones
- 24 October 2007
- journal article
- concept
- Published by Wiley in Chemistry – A European Journal
- Vol. 13 (32), 8920-8926
- https://doi.org/10.1002/chem.200700840
Abstract
The Biginelli reaction, known for over 100 years, is an important multicomponent reaction for accessing dihydropyrimidinones (DHPMs). The individual enantiomers of DHPMs exhibit different or even opposite pharmaceutical activities, which require synthetic methods to easily access the optically pure DHPMs. In recent decades, many efforts have focused on developing procedures for the preparation of optically active Biginelli products. In this article, we will summarize the developments in the synthetic methods to access optically active DHPMs with an emphasis on the recent advances in the asymmetric catalytic Biginelli reactions, along with concepts to design the organocatalytic asymmetric variants.This publication has 37 references indexed in Scilit:
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