Efficient synthesis of the optically active dihydropyrimidinone of a potent α1A- selective adrenoceptor antagonist
- 1 June 2002
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 80 (6), 646-652
- https://doi.org/10.1139/v02-079
Abstract
The convergent synthesis of a potent α1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesis of 2,4'-dipyridyl.Key words: dihydropyrimidinone, enzymatic resolution, palladium coupling.Keywords
This publication has 17 references indexed in Scilit:
- In vitro studies on L-771,688 (SNAP 6383), a new potent and selective α1A-adrenoceptor antagonistEuropean Journal of Pharmacology, 2000
- Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective α1a-receptor antagonistsBioorganic & Medicinal Chemistry Letters, 2000
- Subtype selective α1-adrenoceptor antagonists for the treatment of benign prostatic hyperplasiaExpert Opinion on Investigational Drugs, 1999
- Pharmacological Options in the Treatment of Benign Prostatic HyperplasiaJournal of Medicinal Chemistry, 1997
- Discovery of .alpha.1a-Adrenergic Receptor Antagonists Based on the L-Type Ca2+ Channel Antagonist NiguldipineJournal of Medicinal Chemistry, 1995
- Preparation of π-deficient heteroarylzinc halides by oxidative addition of active zinc and its palladium-catalyzed reactionTetrahedron, 1993
- Pyridinylzinc halides by oxidative addition of active zinc with halopyridinesTetrahedron Letters, 1992
- Synthesis and reactions of biginelli compounds −5. Facile preparation and resolution of a stable 5-dihydropyrimidinecarboxylic acid.Tetrahedron, 1992
- A Convenient Synthesis of 2,4'-BipyridineHETEROCYCLES, 1990
- Selective carbon-carbon bond formation via transition metal catalysis. 3. A highly selective synthesis of unsymmetrical biaryls and diarylmethanes by the nickel- or palladium-catalyzed reaction of aryl- and benzylzinc derivatives with aryl halidesThe Journal of Organic Chemistry, 1977