Protein kinases: A diverse family of related proteins
- 1 July 1987
- Vol. 7 (1), 24-29
- https://doi.org/10.1002/bies.950070106
Abstract
Homologies in amino‐acid sequence indicate that all known protein kinases share a conserved catalytic core, and, thus, belong to a related family of proteins that have evolved in part from a common ancestoral origin. This family includes cellular kinases, oncogenic viral kinases and their protooncogene counterparts, and growth factor receptors. One of the simplest and certainly the best characterized of the protein kinases at the biochemical level is the kinase that is activated in response to cAMP. The properties of this cAMP‐dependent protein kinase are reviewed with particular emphasis on the features of nucleotide binding and catalytic mechanism that are likely to be shared by all protein kinases. In spite of this conserved catalytic core, these kinases vary widely in overall structure and in the mechanisms by which each is regulated, and these differences also are compared.Keywords
This publication has 28 references indexed in Scilit:
- Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformationCell, 1986
- Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanismsCell, 1986
- Prediction of the occurrence of the ADP-binding βαβ-fold in proteins, using an amino acid sequence fingerprintJournal of Molecular Biology, 1986
- Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinaseBiochemistry, 1985
- Crystallization studies of cAMP-dependent protein kinase: Crystals of catalytic subunit diffract to 3.5 Å resolutionJournal of Molecular Biology, 1985
- Human insulin receptor and its relationship to the tyrosine kinase family of oncogenesNature, 1985
- Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsNature, 1984
- Mechanistic Studies of cAMP-Dependent Protein Kinase ActioCritical Reviews in Biochemistry, 1984
- Protein phosphorylation and the control of glycogen metabolism in skeletal musclePhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1983
- Chemical and biological evolution of a nucleotide-binding proteinNature, 1974