Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
- 1 February 1985
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 313 (6005), 756-761
- https://doi.org/10.1038/313756a0
Abstract
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.Keywords
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