Electrical Stimulation of Salivary Flow in Patients with Sjögren's Syndrome
- 1 October 1988
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 67 (10), 1334-1337
- https://doi.org/10.1177/00220345880670101701
Abstract
Patients with the salivary component of Sjögren's syndrome (SS) develop chronic xerostomia, which causes oral symptoms and functional impairment in approximate proportion to its severity. The purpose of this double-blind study was to determine whether an electrical stimulus applied to the tongue and hard palate by a battery-operated device (SAL II, Biosonics, Inc.) could stimulate salivary flow in subjects with generally severe SS. Twenty-nine patients with the salivary component of SS (diagnosed as the presence of focal chronic sialadenitis in a labial salivary gland biopsy specimen with a focus score of > 1 focus/4 mm2) were randomly assigned active or placebo devices, which they used for three minutes, three times a day for four weeks. Whole saliva flow rates were measured at weeks 0, 2, and 4 by collection of whole saliva both before and after stimulation with the device. Twenty-four subjects completed the study. The change in mean post-stimulation flow rate from week 0 to week 4 was greater for the 13 subjects using an active device (0.08 ± S.D. 0.08 gl2 min, to 0.24 ± 0.33 gl2 min) than for the 11 subjects using a placebo device (0.11 ± 0.15 gl2 min, to 0.08 ± 0.18 gl2 min) (p = 0.04). However, the magnitude of the mean difference was small, because three subjects using active devices responded and others did not. Only five subjects, all using active devices, reported a subjective increase in the amount of their saliva. The results of this study indicate that some SS patients with residual salivary flow show a significant response to electrical stimulation, but others with low or absent whole saliva flow rates do not respond.Keywords
This publication has 11 references indexed in Scilit:
- Effectiveness of pilocarpine in postradiation xerostomiaCancer, 1987
- The Proper Role of Nerves in Salivary Secretion: A ReviewJournal of Dental Research, 1987
- Nerve Interactions in Salivary GlandsJournal of Dental Research, 1987
- Pilocarpine for the treatment of xerostomia associated with salivary gland dysfunctionOral Surgery, Oral Medicine, Oral Pathology, 1986
- Xerostomia: evaluation of a symptom with increasing significanceThe Journal of the American Dental Association, 1985
- Labial salivary gland biopsy in sjögren's syndromeArthritis & Rheumatism, 1984
- Prevalence and intraoral distribution of Candida albicans in Sjogren's syndrome.Journal of Clinical Pathology, 1980
- The oral component of Sjögren's syndromeOral Surgery, Oral Medicine, Oral Pathology, 1975
- The histopathology of Sjögren's syndrome in labial salivary gland biopsiesOral Surgery, Oral Medicine, Oral Pathology, 1974
- An investigation of human parotid saliva secretion rate in response to different types of stimulationArchives of Oral Biology, 1969