Labial salivary gland biopsy in sjögren's syndrome
- 1 February 1984
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 27 (2), 147-156
- https://doi.org/10.1002/art.1780270205
Abstract
Xerostomia is an unsatisfactory diagnostic criterion for the salivary component of Sjögren's syndrome (SS). To determine the diagnostic usefulness of the presence of focal sialadenitis in labial salivary gland (LSG) biopsy specimens, 362 patients suspected of having SS prospectively underwent a unique LSG biopsy procedure. The pattern and severity of LSG inflammation were compared with measurements of parotid flow rate, and the presence or absence of symptomatic xerostomia, major salivary gland enlargement, keratoconjunctivitis sicca (KCS), and other connective tissue diseases (CTD). LSG biopsy focus scores of >1 correlated more closely with the diagnoses of KCS alone and with KCS plus a CTD than did either reduced parotid flow rate or symptoms of xerostomia (P < 0.0005 and P < 0.05, respectively). Focal sialadenitis in an adequate LSG specimen is an objective criterion and a more disease-specific feature of SS than xerostomia or any other feature of salivary disease. The salivary component of SS should be redefined as the presence of LSG focal sialadenitis.Keywords
This publication has 34 references indexed in Scilit:
- The incidence of sjögren's sicca complex in a population of patients with keratoconjunctivitis siccaArthritis & Rheumatism, 1982
- Spectrum of Sjögren syndrome in childrenThe Journal of Pediatrics, 1981
- Electrophoretic Protein Pattern of Human Parotid Saliva in Sjögrens Syndrome and SialosisActa Oto-Laryngologica, 1980
- Biopsy of Minor Salivary Glands in the Diagnosis of SarcoidosisNew England Journal of Medicine, 1979
- Genetic Differences between Primary and Secondary Sicca SyndromeNew England Journal of Medicine, 1979
- IgA rheumatoid factor in the sera and saliva of patients with rheumatoid arthritis and Sjogren's syndrome.Annals Of The Rheumatic Diseases, 1979
- Labial sialadenitis in sjögren's syndrome and in rheumatoid arthritisThe Journal of Pathology, 1973
- Lymphocytic sialadenitis in the major and minor glands: a correlation in postmortem subjectsJournal of Clinical Pathology, 1970
- Labial salivary gland biopsy in Sjogren's diseaseJournal of Clinical Pathology, 1968
- Sjogren's syndrome. A case report with an additional diagnostic aidArchives of Internal Medicine, 1966