Polymicrobial Prosthetic Joint Infections: Risk Factors and Outcome
- 1 June 2008
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Orthopaedics and Related Research
- Vol. 466 (6), 1397-1404
- https://doi.org/10.1007/s11999-008-0230-7
Abstract
Limited data are available regarding the risk factors and outcome of polymicrobial prosthetic joint infection (PJIs) when compared with monomicrobial PJI. Between January 1998 and November 2006, we retrospectively identified 34 of 174 prosthetic joint infections (19%) were polymicrobial. The 2-year cumulative probability of success of treating polymicrobial and monomicrobial PJIs was 63.8% and 72.8%, respectively. Twenty-six percent, 38%, and 29% of PJIs were treated with two-stage exchange, débridement and retention, or resection arthroplasty, respectively, and the 2-year survival rate free of treatment failure in each group was 77.7% (95% confidence interval, 42.8%–94.2%), 52.7% (95% confidence interval, 28.4%–75.9%), and 64.2% (95% confidence interval, 28.7%–88.9%). Methicillin-resistant Staphylococcus aureus (26.4% versus 7.1%) and anaerobes (11.7% versus 2.8%) were more common in polymicrobial PJIs. Polymicrobial PJIs occurred in patients with a soft tissue defect/dehiscence (23.5% versus 2.8%), drainage (79.4% versus 39.2%), or prior local irradiation (8.8% versus 0.71%). We found the following factors associated with polymicrobial prosthetic joint infections: the presence of a soft tissue defect/wound dehiscence (odds ratio, 5.9), drainage (odds ratio, 5.0), and age 65 years or older (odds ratio, 2.8). Level of Evidence: Level III, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.Keywords
This publication has 24 references indexed in Scilit:
- Higher Risk of Failure of Methicillin-resistant Staphylococcus aureus Prosthetic Joint InfectionsClinical Orthopaedics and Related Research, 2007
- Guiding empirical antibiotic therapy in orthopaedics: The microbiology of prosthetic joint infection managed by debridement, irrigation and prosthesis retentionJournal of Infection, 2007
- Septic Arthritis in Patients Aged 80 and Older: A Comparison with Younger AdultsJournal of the American Geriatrics Society, 2005
- Polymicrobial Deep Joint Replacement Infection Temporally Associated With Building Construction: A Case SeriesInfection Control & Hospital Epidemiology, 2005
- Prosthetic Joint Infections: Bane of Orthopedists, Challenge for Infectious Disease SpecialistsClinical Infectious Diseases, 2003
- Infection of prosthetic jointsBest Practice & Research Clinical Rheumatology, 2003
- Periprosthetic Total Joint InfectionsClinical Orthopaedics and Related Research, 2002
- Risk Factors for Prosthetic Joint Infection: Case‐Control StudyClinical Infectious Diseases, 1998
- Incidence and sources of native and prosthetic joint infection: a community based prospective surveyAnnals Of The Rheumatic Diseases, 1997
- Factors Influencing the Incidence and Outcome of Infection Following Total Joint ArthroplastyClinical Orthopaedics and Related Research, 1984