Prevalence and Risk Factors for Vitamin C Deficiency in North and South India: A Two Centre Population Based Study in People Aged 60 Years and Over
Open Access
- 6 December 2011
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 6 (12), e28588
- https://doi.org/10.1371/journal.pone.0028588
Abstract
Studies from the UK and North America have reported vitamin C deficiency in around 1 in 5 men and 1 in 9 women in low income groups. There are few data on vitamin C deficiency in resource poor countries. To investigate the prevalence of vitamin C deficiency in India. We carried out a population-based cross-sectional survey in two areas of north and south India. Randomly sampled clusters were enumerated to identify people aged 60 and over. Participants (75% response rate) were interviewed for tobacco, alcohol, cooking fuel use, 24 hour diet recall and underwent anthropometry and blood collection. Vitamin C was measured using an enzyme-based assay in plasma stabilized with metaphosphoric acid. We categorised vitamin C status as deficient (28 µmol/L). We investigated factors associated with vitamin C deficiency using multivariable Poisson regression. The age, sex and season standardized prevalence of vitamin C deficiency was 73.9% (95% confidence Interval, CI 70.4,77.5) in 2668 people in north India and 45.7% (95% CI 42.5,48.9) in 2970 from south India. Only 10.8% in the north and 25.9% in the south met the criteria for adequate levels. Vitamin C deficiency varied by season, and was more prevalent in men, with increasing age, users of tobacco and biomass fuels, in those with anthropometric indicators of poor nutrition and with lower intakes of dietary vitamin C. In poor communities, such as in our study, consideration needs to be given to measures to improve the consumption of vitamin C rich foods and to discourage the use of tobacco.Keywords
This publication has 42 references indexed in Scilit:
- Prevalence of Cataract in an Older Population in India: The India Study of Age-related Eye DiseaseOphthalmology, 2011
- Chronic diseases and injuries in IndiaThe Lancet, 2011
- Genetic variation at the SLC23A1 locus is associated with circulating concentrations of l-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participantsThe American Journal of Clinical Nutrition, 2010
- Nutritional composition of the diets of South Asian, black African-Caribbean and white European children in the United Kingdom: The Child Heart and Health Study in England (CHASE)British Journal of Nutrition, 2010
- Malnutrition in free-living elderly in rural south India: prevalence and risk factorsPublic Health Nutrition, 2009
- Random Capillary Blood Glucose Cut Points for Diabetes and Pre-Diabetes Derived From Community-Based Opportunistic Screening in IndiaDiabetes Care, 2008
- Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysisNutrition Journal, 2007
- Nutritional Status of the Tribal Elderly in IndiaJournal of Nutrition For the Elderly, 2006
- Vitamin losses: Retention during heat treatment and continual changes expressed by mathematical modelsJournal of Food Composition and Analysis, 2006
- Are lifestyle factors good predictors of retinol and vitamin C deficiency in apparently healthy adults?European Journal of Clinical Nutrition, 2002