Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
- 15 May 2012
- journal article
- research article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 22 (10), 3437-3440
- https://doi.org/10.1016/j.bmcl.2012.03.104
Abstract
No abstract availableKeywords
This publication has 7 references indexed in Scilit:
- Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodentsNeurochemistry International, 2011
- Recent Advances in the Development of Dopamine D3Receptor Antagonists: a Medicinal Chemistry PerspectiveChemMedChem, 2011
- Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical ProfileThe Journal of pharmacology and experimental therapeutics, 2010
- Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 2008
- Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: II. behavioural characterisation of RG-15Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 2008
- Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profileBioorganic & Medicinal Chemistry Letters, 2007
- Dopamine D3 receptor ligands—Recent advances in the control of subtype selectivity and intrinsic activityBiochimica et Biophysica Acta (BBA) - Biomembranes, 2007