Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results
Open Access
- 7 June 2012
- journal article
- research article
- Published by Hindawi Limited in International Journal of Endocrinology
- Vol. 2012, 1-10
- https://doi.org/10.1155/2012/408295
Abstract
Background. Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity, and the role of calcium and parathyroid hormone is still controversial.Objective. To evaluate the prevalence and outcomes of metabolic syndrome, hypertension, and some cardiovascular alterations in asymptomatic PHPT, and specific changes after successful parathyroidectomy.Material and Methods. We examined 30 newly diagnosed PHPT patients (8 males, 22 females; mean age yrs), 30 patients with essential hypertension (EH) (9 males, 21 females; mean age ), and 30 normal subjects (NS) (9 males, 21 females: mean age ). All groups underwent evaluation with ambulatory monitoring blood pressure, echocardiography, and color-Doppler artery ultrasonography and were successively revaluated after one year from parathyroidectomy.Results. PHPT patients presented a higher prevalence of metabolic syndrome (38%) with respect to EH (28%). Prevalence of hypertension in PHPT was 81%, and 57% presented altered circadian rhythm of blood pressure, with respect to EH (35%) and NS (15%). PHPT showed an important myocardial and vascular remodelling. During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and “non-dipping phenomenon.”Conclusions. Cardiovascular and metabolic alterations should be considered as added parameters in evaluation of patients with asymptomatic PHPT.Keywords
This publication has 62 references indexed in Scilit:
- Hypertension Secondary to PHPT: Cause or Coincidence?International Journal of Endocrinology, 2011
- Improvement of Hypertension after Parathyroidectomy of Patients Suffering from Primary HyperparathyroidismInternational Journal of Endocrinology, 2011
- Cardiac function in mild primary hyperparathyroidism and the outcome after parathyroidectomyActa Endocrinologica, 2010
- Parathyroidectomy decreases systolic and diastolic blood pressure in hypertensive patients with primary hyperparathyroidismSurgery, 2009
- Carotid Vascular Abnormalities in Primary HyperparathyroidismJournal of Clinical Endocrinology & Metabolism, 2009
- Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism: Summary Statement from the Third International WorkshopJournal of Clinical Endocrinology & Metabolism, 2009
- Time course of regression of left ventricular hypertrophy after successful parathyroidectomySurgery, 1997
- Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO reportOsteoporosis International, 1994
- Primary hyperparathyroidism in younger and older patients: Symptoms and outcome of surgeryWorld Journal of Surgery, 1992
- The Relationship Between Primary Hyperparathyroidism and Diabetes MellitusAnnals of Surgery, 1988