Metastatic Cancer Cell
- 1 February 2008
- journal article
- review article
- Published by Annual Reviews in Annual Review Of Pathology-Mechanisms Of Disease
- Vol. 3 (1), 221-247
- https://doi.org/10.1146/annurev.pathmechdis.3.121806.151523
Abstract
Metastasis is the result of cancer cell adaptation to a tissue microenvironment at a distance from the primary tumor. Metastatic cancer cells require properties that allow them not only to adapt to a foreign microenvironment but to subvert it in a way that is conducive to their continued proliferation and survival. Recent conceptual and technological advances have contributed to our understanding of the role of the host tissue stroma in promoting tumor cell growth and dissemination and have provided new insight into the genetic makeup of cancers with high metastatic proclivity.Keywords
This publication has 101 references indexed in Scilit:
- Stromal fibroblasts in cancer initiation and progressionNature, 2004
- Cytokines in cancer pathogenesis and cancer therapyNature Reviews Cancer, 2004
- JNK phosphorylates paxillin and regulates cell migrationNature, 2003
- Tumour-cell invasion and migration: diversity and escape mechanismsNature Reviews Cancer, 2003
- Inflammation and cancerNature, 2002
- A molecular signature of metastasis in primary solid tumorsNature Genetics, 2002
- Integrins: Bidirectional, Allosteric Signaling MachinesCell, 2002
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002
- Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisCell, 1996
- Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppressionNature Medicine, 1995