Linkage analysis with misclassification at one locus
- 1 August 1977
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 12 (2), 119-124
- https://doi.org/10.1111/j.1399-0004.1977.tb00913.x
Abstract
It is demonstrated that in linkage analyses with a misclassification error p of the phenotypes at one locus, a wrong specification of p leads to a bias in the estimate of the recombination fraction. In particular, if p is not taken into account at all in the analysis, the recombination fraction is overestimated. This is shown for offspring of phase‐known double backcross matings. In the light of these results, the possible effects of dichotomization of quantitative phenotypes are discussed and illustrated with an example of the linkage between hypercholesterolemia and C3.This publication has 7 references indexed in Scilit:
- Counting methods (EM algorithm) in human pedigree analysis: Linkage and segregation analysisAnnals of Human Genetics, 1977
- A Comparison of Iterative Maximum Likelihood Estimates of the Parameters of a Mixture of Two Normal Distributions Under Three Different Types of SamplePublished by JSTOR ,1973
- Hyperlipidemia in Coronary Heart Disease I. LIPID LEVELS IN 500 SURVIVORS OF MYOCARDIAL INFARCTIONJCI Insight, 1973
- Familial Hypercholesterolemia in a Large KindredAnnals of Internal Medicine, 1972
- The normal range—A common misuseJournal of Chronic Diseases, 1967
- COUNTING METHODS IN GENETICAL STATISTICSAnnals of Human Genetics, 1957
- THE ESTIMATION OF GENE FREQUENCIES IN A RANDOM‐MATING POPULATIONAnnals of Human Genetics, 1955