Hyperlipidemia in Coronary Heart Disease I. LIPID LEVELS IN 500 SURVIVORS OF MYOCARDIAL INFARCTION
Open Access
- 1 July 1973
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 52 (7), 1533-1543
- https://doi.org/10.1172/jci107331
Abstract
Plasma cholesterol and triglyceride levels were measured after an overnight fast in 500 consecutively studied 3-mo survivors of myocardial infarction. Virtually all patients under 60 yr of age (95% ascertainment) and a randomly chosen group of older survivors admitted to 13 Seattle hospitals during an 11 mo period were included. A comparison of their lipid values with those of 950 controls demonstrated that 31% had hyperlipidemia. These lipid abnormalities were most commonly found in males under 40 yr of age (60% frequency) and in females under 50 yr of age (60% frequency). Elevation in triglyceride levels with (7.8%) or without (15.6%) an associated elevation in cholesterol levels was three times more common in survivors than a high cholesterol level alone (7.6%). These results raise the possibility that hypertriglyceridemia may be as an important a risk factor for coronary atherosclerosis as hypercholesterolemia. The identification of hyperlipidemic survivors of myocardial infarction provided a unique source of probands for family studies designed to disclose the genetic origin of hyperlipidemia in coronary heart disease.Keywords
This publication has 39 references indexed in Scilit:
- Genetics of hyperlipidemia in coronary heart disease.1972
- Serial lipid and lipoprotein responses to the American Heart Association fat-controlled dietAmerican Journal Of Medicine, 1971
- Studies of male survivors of myocardial infarction. XII. Relation of serum lipids and lipoproteins to survival over a 10-year period.1970
- SERUM LIPOPROTEIN PATTERN IN MYOCARDIAL INFARCTIONActa Medica Scandinavica, 1970
- Studies on the Mechanism of Increased Plasma Triglyceride Levels Induced by Oral ContraceptivesNew England Journal of Medicine, 1969
- The Stockholm prospective study. 1. The initial values for plasma lipids.1968
- Coronary Angiographic Findings in Correlation with Age, Body Weight, Blood Pressure, Serum Lipids, and Smoking HabitsCirculation, 1966
- Serum Triglycerides in Health and in Ischemic Heart DiseaseNew England Journal of Medicine, 1965
- The aetiology of essential hypertension. 4. The role of inheritance.1954
- Hypercholesteremia with predisposition to atherosclerosis: An inborn error of lipid metabolismAmerican Journal Of Medicine, 1951