Herpes zoster infection after liver transplantation: A case-control study
Open Access
- 17 February 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Liver Transplantation
- Vol. 11 (3), 320-325
- https://doi.org/10.1002/lt.20356
Abstract
Prior case series have suggested that herpes zoster (HZ) after orthotopic liver transplantation (OLT) may lead to serious complications due to visceral involvement. We sought to determine the incidence, risk factors, and long term outcomes of HZ after OLT. Clinical data from September 1993 to April 2004 were collected on all cases of HZ after OLT, and at the same post-OLT time points in age, gender, and transplant-year–matched HZ-negative controls. Risk factors for HZ infection and long-term outcomes were compared between cases and controls. A total of 29 patients developed HZ at a median of 4.9 years (range .5–12.9) after OLT. All HZ infections except 1 were localized to a single dermatome. Only 8 (28%) were hospitalized and 16 (55%) were treated with oral antivirals alone. No patients developed visceral involvement or died of HZ infection. No risk factors for HZ infection were identified on multivariate analysis. Of the long-term outcomes, the estimated 10-year survival was lower (P = .05) for cases than controls. The lower survival in HZ cases was not directly attributable to HZ infection. In conclusion, this study is the largest series on HZ after OLT. HZ is neither a common nor a serious infection after OLT and can be managed with antiviral therapy with a low likelihood of visceral dissemination. (Liver Transpl 2005;11:320–325.)Keywords
This publication has 21 references indexed in Scilit:
- Herpes zoster after liver transplantation: Incidence, risk factors, and complicationsLiver Transplantation, 2004
- Clinical manifestations of varicellaPublished by Cambridge University Press (CUP) ,2000
- Infectious Ocular Complications in Orthotopic Liver Transplant PatientsClinical Infectious Diseases, 1997
- Shingles in one family practiceArchives of Family Medicine, 1996
- Herpes zoster-associated idiopathic thrombocytopenic purpura in a liver transplant recipient: a case report and overviewTransplant International, 1995
- Herpes Zoster and Human Immunodeficiency Virus InfectionThe Journal of Infectious Diseases, 1992
- High incidence of herpes zoster in patients with systemic lupus erythematosus: an immunological analysis.Annals Of The Rheumatic Diseases, 1990
- RISK OF AIDS AFTER HERPES ZOSTERThe Lancet, 1987
- Infection with Varicella-Zoster Virus After Marrow TransplantationThe Journal of Infectious Diseases, 1985
- Population-Based Study of Herpes Zoster and Its SequelaeMedicine, 1982