Herpes zoster after liver transplantation: Incidence, risk factors, and complications
Open Access
- 30 August 2004
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Liver Transplantation
- Vol. 10 (9), 1140-1143
- https://doi.org/10.1002/lt.20219
Abstract
Herpes zoster is the consequence of the reactivation of latent varicella-zoster infection. Immunosuppression may be a predisposing factor for herpes zoster. We have retrospectively assessed the risk of herpes zoster, the risk factors for its occurrence, and its evolution in a population of 209 consecutive liver transplant recipients. Herpes zoster developed in 25 (12%) of patients. One-, 3-, 5-, and 10-year actuarial rates of herpes zoster were 3%, 10%, 14%, and 18%, respectively. In a case-control study, patients developing herpes zoster were younger, received a higher number of immunosuppressive drugs, and were more frequently receiving mycophenolate mofetil or azathioprine. In multivariate analysis, the only factor related to herpes zoster occurrence was treatment with mycophenolate mofetil or azathioprine. Eight patients (31%) developed postherpetic neuralgia. In conclusion, herpes zoster is a relateively common complication after liver transplantation. It is related to immunosuppressive therapy. Postherpetic neuralgia develops in one third of patients with posttransplant herpes zoster. (Liver Transpl 2004;10:1140–1143.)Keywords
This publication has 10 references indexed in Scilit:
- Herpes Zoster Infection Following Solid Organ Transplantation: Incidence, Risk Factors and Outcomes in the Current Immunosuppressive EraAmerican Journal of Transplantation, 2004
- Liver Transplant Recipients Older Than 60 Years Have Lower Survival and Higher Incidence of MalignancyAmerican Journal of Transplantation, 2003
- Herpes ZosterNew England Journal of Medicine, 2002
- Prognostic model for early acute rejection after liver transplantationLiver Transplantation, 2001
- Neurologic Complications of the Reactivation of Varicella–Zoster VirusNew England Journal of Medicine, 2000
- Conversion of liver transplant recipients on cyclosporine with renal impairment to mycophenolate mofetilLiver Transplantation and Surgery, 1999
- Postherpetic Neuralgia — Pathogenesis, Treatment, and PreventionNew England Journal of Medicine, 1996
- The Incidence of Herpes ZosterArchives of Internal Medicine, 1995
- Herpes Zoster and Human Immunodeficiency Virus InfectionThe Journal of Infectious Diseases, 1992
- Population-Based Study of Herpes Zoster and Its SequelaeMedicine, 1982