Applications of upconversion nanoparticles in imaging, detection and therapy
- 31 August 2011
- journal article
- review article
- Published by Informa UK Limited in Nanomedicine
- Vol. 6 (7), 1273-1288
- https://doi.org/10.2217/NNM.11.108
Abstract
Upconversion nanoparticles (UCNs) are an emerging class of luminescent nanomaterials, exhibiting many advantages over conventional fluorophores, such as high signal-to-noise ratio and superior photostability. The near-infrared excitation wavelengths of these particles offer additional advantages such as deep tissue penetration and low photodamage to biological samples. In the last 5 years, with the advances in nanoparticles synthesis and modification technology, much research has been performed to exploit UCNs' advantages and integrate them into various biological applications. This review focuses on the recent developments of UCNs as imaging, detection and therapeutic tools, highlighting the respective strategies adopted.Keywords
This publication has 94 references indexed in Scilit:
- Controllable synthesis of NaYF4 : Yb,Er upconversion nanophosphors and their application to in vivo imaging of Caenorhabditis elegansJournal of Materials Chemistry, 2011
- Highly sensitive and selective label-free optical detection of mercuric ions using photon upconverting nanoparticlesBiosensors and Bioelectronics, 2010
- NIR-Responsive Silica-Coated NaYbF4:Er/Tm/Ho Upconversion Fluorescent Nanoparticles with Tunable Emission Colors and Their Applications in Immunolabeling and Fluorescent Imaging of Cancer CellsThe Journal of Physical Chemistry C, 2009
- Upconverting luminescent nanomaterials: application to in vivo bioimagingChemical Communications, 2009
- A timer-actuated immunoassay cassette for detecting molecular markers in oral fluidsLab on a Chip, 2008
- High Contrast in Vitro and in Vivo Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm3+ and Yb3+ Doped Fluoride NanophosphorsNano Letters, 2008
- Highly sensitive and selective oligonucleotide sensor for sickle cell disease gene using photon upconverting nanoparticlesBiosensors and Bioelectronics, 2008
- A user-friendly, highly sensitive assay to detect the IFN-γ secretion by T cellsClinical Biochemistry, 2008
- Up-Converting Phosphor Technology-Based Lateral Flow Assay for Detection of Schistosoma Circulating Anodic Antigen in SerumJournal of Clinical Microbiology, 2008
- Versatile Photosensitizers for Photodynamic Therapy at Infrared ExcitationJournal of the American Chemical Society, 2007