Versatile Photosensitizers for Photodynamic Therapy at Infrared Excitation
Top Cited Papers
- 27 March 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 129 (15), 4526-4527
- https://doi.org/10.1021/ja0700707
Abstract
A new type of photosensitizers used in photodynamic therapy, which is based on photon upconverting nanoparticles, is reported. These photosensitizers are excitable with infrared irradiation and have several times larger tissue penetration depth than the currently available ones. They are brought close to the target cancer cells through antigen−antibody interaction with good specificity and versatility. The design is also flexible in that various photosensitive molecules can be potentially adopted into the design. Results from in vitro experiments demonstrate their promise of becoming the next generation photodynamic therapy drugs.Keywords
This publication has 16 references indexed in Scilit:
- Nanoparticles for Two-Photon Photodynamic Therapy in Living CellsNano Letters, 2006
- Intracellular photodynamic therapy with photosensitizer-nanoparticle conjugates: cancer therapy using a ‘Trojan horse’Photochemical & Photobiological Sciences, 2006
- Photodynamic Characterization and In Vitro Application of Methylene Blue-containing Nanoparticle Platforms¶Photochemistry and Photobiology, 2005
- Highly Efficient Multicolour Upconversion Emission in Transparent Colloids of Lanthanide‐Doped NaYF4 NanocrystalsAdvanced Materials, 2004
- Upconversion and Anti-Stokes Processes with f and d Ions in SolidsChemical Reviews, 2003
- Ceramic-Based Nanoparticles Entrapping Water-Insoluble Photosensitizing Anticancer Drugs: A Novel Drug−Carrier System for Photodynamic TherapyJournal of the American Chemical Society, 2003
- Photodynamic therapeutics: basic principles and clinical applicationsDrug Discovery Today, 1999
- Two-photon excitation of alkyl-substituted magnesium phthalocyanine: radical formation via higher excited statesJournal of Photochemistry and Photobiology A: Chemistry, 1994
- Photodynamic Action of Merocyanine 540 on Leukemia Cells: Iron-Stimulated Lipid Peroxidation and Cell KillingArchives of Biochemistry and Biophysics, 1993
- Determination of the lifetime of singlet oxygen in water-d2 using 9,10-anthracenedipropionic acid, a water-soluble probeJournal of the American Chemical Society, 1980