Functional conservation of mouse Notch receptor family members
Open Access
- 21 October 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 395 (2-3), 221-224
- https://doi.org/10.1016/0014-5793(96)01046-0
Abstract
All the known members of the mouse Notch receptor family were examined for their biochemical function by interaction with a DNA binding protein RBP‐Jκ. mNotch2, mNotch3 and int3 (= mNotch4) were shown to interact with RBP‐Jκ by the GST‐fusion pull down assay and dominant negative competition with Epstein Barr virus nuclear antigen 2. Furthermore the intracellular region of int3 was shown to transactivate the Epstein Barr virus TP1 promoter. These results indicate that all mouse Notch family members have biochemical functions similar to mNotch1, which transduces proliferative signal by direct interaction with the DNA binding protein RBP‐Jκ.This publication has 27 references indexed in Scilit:
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