Preliminary Observations on the Effect of Recombinant Leukocyte a Interferon in Homosexual Men with Kaposi's Sarcoma

Abstract

Preliminary clinical trials have shown that both natural and recombinant-DNA-produced human interferons are occasionally capable of inhibiting the growth of some tumors.^{1 2 3 4} Although the tumors responding to interferon have most often been those without evidence for a viral association, case reports have appeared of therapeutic effects in patients with nasopharyngeal carcinoma,⁵ for which there is strong serologic evidence supporting a viral association, and in patients with laryngeal papilloma,⁶ for which the available evidence supports a viral pathogenesis. Interferons have also been shown to modify the course of chronic viral infections in human beings, including infections induced by hepatitis B virus . . .