Defining Treatment Response in Pediatric Tic Disorders: A Signal Detection Analysis of the Yale Global Tic Severity Scale
- 1 December 2011
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Child and Adolescent Psychopharmacology
- Vol. 21 (6), 621-627
- https://doi.org/10.1089/cap.2010.0149
Abstract
Objective: To examine the optimal Yale Global Tic Severity Scale (YGTSS) percent reduction and raw cutoffs for predicting treatment response among children and adolescents with tic disorders. Method: Youth with a tic disorder (N=108; range=5–17 years) participated in several clinical trials involving varied medications or psychosocial treatment, or received naturalistic care. Assessments were conducted before and after treatment and included the YGTSS and response status on the Clinical Global Impressions-Improvement Scale (CGI-I). Results: A 35% reduction on the YGTSS total tic severity score or a YGTSS raw total tic severity score change of 6 or 7 points were the best indicators of clinical treatment response in youth with tic disorders. Conclusions: A YGTSS total tic severity score reduction of 35% or a raw total tic severity score change of 6 or 7 appears optimal for determining treatment response. A consistent definition of treatment response on the YGTSS may facilitate cross-study comparability. Practitioners can use these values for treatment planning decisions (e.g., change medications, etc.).This publication has 16 references indexed in Scilit:
- Treatment of Tics and Tourette SyndromeCurrent Treatment Options in Neurology, 2010
- Behavior Therapy for Children With Tourette DisorderJAMA, 2010
- Open Label Aripiprazole in the Treatment of Youth with Tic DisordersJournal of Child and Adolescent Psychopharmacology, 2009
- Effectiveness and Tolerability of Open Label Olanzapine in Children and Adolescents with Tourette SyndromeJournal of Child and Adolescent Psychopharmacology, 2008
- Defining Response in Clinical Trials for Obsessive-Compulsive DisorderBritish Journal of Psychology, 2005
- A placebo-controlled trial of risperidone in Tourette syndromeNeurology, 2003
- Kappa coefficients in medical researchStatistics in Medicine, 2002
- A Placebo-Controlled Study of Guanfacine in the Treatment of Children With Tic Disorders and Attention Deficit Hyperactivity DisorderAmerican Journal of Psychiatry, 2001
- The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.1998
- Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity DataJournal of the American Academy of Child & Adolescent Psychiatry, 1997