A placebo-controlled trial of risperidone in Tourette syndrome
- 8 April 2003
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 60 (7), 1130-1135
- https://doi.org/10.1212/01.wnl.0000055434.39968.67
Abstract
Objective: To evaluate the efficacy and safety of risperidone in children and adults with Tourette syndrome. Methods: This was an 8-week, randomized, double-blind, placebo-controlled trial. The primary outcome measure was the Total Tic score of the Yale Global Tic Severity Scale (YGTSS). Results: Thirty-four medication-free subjects (26 children and 8 adults) ranging in age from 6 to 62 years (mean = 19.7 ± 17.0 years) participated. YGTSS Total Tic scores were similar at baseline (26.0 ± 5.1 for risperidone vs 27.4 ± 8.5 for placebo). After 8 weeks of treatment (mean daily dose of 2.5 ± 0.85), the 16 subjects on risperidone showed a 32% reduction in tic severity from baseline, compared to a 7% reduction for placebo patients (n = 18) (F[2,64] = 6.07; p = 0.004). The 12 children randomized to risperidone showed a 36% reduction in tic symptoms compared to an 11% decrease in the 14 children on placebo (F[2,48] = 6.38; p = 0.004). Two children on risperidone showed acute social phobia, which resolved with dose reduction in one subject but resulted in medication discontinuation in the other. A mean increase in body weight of 2.8 kg was observed in the risperidone group compared to no change in placebo (F[2,64] = 10.68; p = 0.0001). No extrapyramidal symptoms and no clinically significant alterations in cardiac conduction times or laboratory measures were observed. Conclusion: Risperidone appears to be safe and effective for short-term treatment of tics in children or adults with Tourette syndrome. Longer-term studies are needed to evaluate the durability of efficacy and safety over time.This publication has 28 references indexed in Scilit:
- Risperidone in Children with Autism and Serious Behavioral ProblemsThe New England Journal of Medicine, 2002
- An Open-Label Study of the Treatment Efficacy of Olanzapine for Tourette's DisorderPublished by Physicians Postgraduate Press, Inc ,2001
- Does Fast Dissociation From the Dopamine D2Receptor Explain the Action of Atypical Antipsychotics?: A New HypothesisAmerican Journal of Psychiatry, 2001
- Risperidone Versus Pimozide in Tourette's DisorderBritish Journal of Psychology, 2001
- Effective open-label treatment of Touretteʼs disorder with olanzapineInternational Clinical Psychopharmacology, 2000
- Separation Anxiety in Children and Adolescents Treated with RisperidoneJournal of Child and Adolescent Psychopharmacology, 1999
- Serotonin‐dopamine antagonist and Gilles de la tourette's syndrome: An open pilot dose‐titration study with risperidoneMovement Disorders, 1994
- Clonidine Treatment of Gilles de la Tourette's SyndromeArchives of General Psychiatry, 1991
- Clonidine and Gilles de la Tourette's syndrome: Double‐blind study using objective rating methodsAnnals of Neurology, 1987
- Tardive Dyskinesia Following Haloperidol Treatment in Tourette's SyndromeArchives of General Psychiatry, 1987