Divergent Synthesis of Quinazolin-4(3H)-ones and Tryptanthrins Enabled by a tert-Butyl Hydroperoxide/K3PO4-Promoted Oxidative Cyclization of Isatins at Room Temperature
- 26 May 2016
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 18 (12), 2942-2945
- https://doi.org/10.1021/acs.orglett.6b01291
Abstract
A synergetic tert-butyl hydroperoxide/K3PO4-promoted oxidative cyclization has been developed for the facile synthesis of various functionalized quinazolin-4(3H)-ones from commercially available isatins and amidine hydrochlorides at room temperature. The synthetic utility of this strategy was illustrated by the convenient synthesis of tryptanthrin derivatives via a self-dimerization of isatins under the same conditions.Keywords
Funding Information
- Central China Normal University (2015YBZD015)
- National Natural Science Foundation of China (21272085, 21472056)
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