PXR Pharmacogenetics: Association of Haplotypes with Hepatic CYP3A4 and ABCB1 Messenger RNA Expression and Doxorubicin Clearance in Asian Breast Cancer Patients
- 1 November 2008
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 14 (21), 7116-7126
- https://doi.org/10.1158/1078-0432.ccr-08-0411
Abstract
Purpose: To characterize pregnane X receptor (PXR) polymorphic variants in healthy Asian populations [Chinese, Malay and Indian (n = 100 each)], and to investigate the association between PXR haplotypes and hepatic mRNA expression of PXR and its downstream target genes, CYP3A4 and ABCB1, as well as their influence on the clearance of doxorubicin in Asian breast cancer patients.Keywords
This publication has 29 references indexed in Scilit:
- Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cellsBritish Journal of Pharmacology, 2008
- The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and ConsequencesAnnual Review of Pharmacology and Toxicology, 2008
- PXR, CAR and HNF4α genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patientsThe Pharmacogenomics Journal, 2007
- CAR and PXR: The xenobiotic-sensing receptorsSteroids, 2007
- Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane X Receptor in Mouse Liver, Kidney, and IntestineDrug Metabolism and Disposition, 2006
- Human CYP2C8 Is Transcriptionally Regulated by the Nuclear Receptors Constitutive Androstane Receptor, Pregnane X Receptor, Glucocorticoid Receptor, and Hepatic Nuclear Factor 4αMolecular Pharmacology, 2005
- Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting Protein 1Molecular Pharmacology, 2004
- Development and Refinement of Pregnane X Receptor (PXR) DNA Binding Site Model Using Information TheoryOnline Journal of Public Health Informatics, 2004
- FUNCTIONAL CHARACTERIZATION OF FOUR NATURALLY OCCURRING VARIANTS OF HUMAN PREGNANE X RECEPTOR (PXR): ONE VARIANT CAUSES DRAMATIC LOSS OF BOTH DNA BINDING ACTIVITY AND THE TRANSACTIVATION OF THE CYP3A4 PROMOTER/ENHANCER REGIONDrug Metabolism and Disposition, 2004
- The Structure of Haplotype Blocks in the Human GenomeScience, 2002