Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature
Top Cited Papers
Open Access
- 28 April 2016
- journal article
- review article
- Published by Hindawi Limited in Case Reports in Neurological Medicine
- Vol. 2016, 1-6
- https://doi.org/10.1155/2016/3502683
Abstract
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism.Keywords
This publication has 17 references indexed in Scilit:
- Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)Infection, 2015
- Molecular pathology of emerging coronavirus infectionsThe Journal of Pathology, 2014
- Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi ArabiaInternational Journal of Infectious Diseases, 2014
- Middle East Respiratory Syndrome: What Clinicians Need to KnowMayo Clinic Proceedings, 2014
- Neuroinvasive and Neurotropic Human Respiratory Coronaviruses: Potential Neurovirulent Agents in HumansPublished by Springer Science and Business Media LLC ,2014
- Middle East Respiratory Syndrome Coronavirus in Bats, Saudi ArabiaEmerging Infectious Diseases, 2013
- Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi ArabiaThe New England Journal of Medicine, 2012
- Virus-induced neuronal dysfunction and degenerationFrontiers in Bioscience-Landmark, 2009
- Role of Cell Culture for Virus Detection in the Age of TechnologyClinical Microbiology Reviews, 2007
- SARS: Systematic Review of Treatment EffectsPLoS Medicine, 2006