Gold nanoparticles: opportunities and challenges in nanomedicine
- 21 April 2010
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Drug Delivery
- Vol. 7 (6), 753-763
- https://doi.org/10.1517/17425241003777010
Abstract
Importance of the field: Site-specific drug delivery is an important area of research that is anticipated to increase the efficacy of the drug and reduce potential side effects. Owing to this, substantial work has been done developing non-invasive and targeted tumor treatment with nanoscale metallic particles. Areas covered in this review: This review focuses on the work done in the last few years developing gold nanoparticles as cancer therapeutics and diagnostic agents. However, there are challenges in using gold nanoparticles as drug delivery systems, such as biodistribution, pharmacokinetics and possible toxicity. Approaches to limit these issues are proposed. What the reader will gain: Different approaches from several different disciplines are discussed. Potential clinical applications of these engineered nanoparticles are also presented. Take home message: As a result of their unique size-dependent physicochemical and optical properties, adaptability, subcellular size and biocompatibility, these nanosized carriers offer a suitable means of transporting small molecules as well as biomacromolecules to diseased cells/tissues.Keywords
This publication has 95 references indexed in Scilit:
- Fabrication and functional characterization of goldnanoconjugates for potential application in ovarian cancerJournal of Materials Chemistry, 2009
- Tamoxifen−Poly(ethylene glycol)−Thiol Gold Nanoparticle Conjugates: Enhanced Potency and Selective Delivery for Breast Cancer TreatmentBioconjugate Chemistry, 2009
- SERS‐Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near‐Infrared Imaging and Photothermal HeatingAdvanced Materials, 2009
- Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod AntennasCancer Research, 2009
- Photoregulated Release of Caged Anticancer Drugs from Gold NanoparticlesJournal of the American Chemical Society, 2009
- Targeted Killing of Cancer Cells in Vivo and in Vitro with EGF-Directed Carbon Nanotube-Based Drug DeliveryACS Nano, 2009
- Entrapment of Hydrophobic Drugs in Nanoparticle Monolayers with Efficient Release into Cancer CellsJournal of the American Chemical Society, 2009
- Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted miceBiomaterials, 2009
- Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of CancerJournal of the American Chemical Society, 2008
- Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisCell, 1996