Action of Rubus coreanus extract on systemic and local anaphylaxis
- 17 September 2002
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 16 (6), 508-513
- https://doi.org/10.1002/ptr.925
Abstract
The effect was investigated of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (RCAE) on systemic and local anaphylaxis. RCAE (0.01–1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. RCAE (1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. Pretreatment with RCAE at the same concentration before systemic anaphylaxis reduced the plasma histamine levels in a dose-dependent manner. RCAE (0.001–1 mg/mL) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMC, when RCAE was added, significantly increased, compared with that of the normal control. Moreover, RCAE (0.01–1 mg/mL) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-α production from RPMC. These results indicate that RCAE may possess antianaphylactic action. Copyright © 2002 John Wiley & Sons, Ltd.Keywords
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