Eft ofSchizonepeta TenuifoliaExtract On Mast Cell-Mediated Immediate-Type Hypersensitivity In Rats
- 1 January 1999
- journal article
- research article
- Published by Informa UK Limited in Immunopharmacology and Immunotoxicology
- Vol. 21 (4), 705-715
- https://doi.org/10.3109/08923979909007136
Abstract
We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose-dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-α production from RPMC.Keywords
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