Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects
- 1 January 2007
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 63 (1), 116-120
- https://doi.org/10.1111/j.1365-2125.2006.02707.x
Abstract
To assess the effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem. In a randomized cross-over study with two phases, 10 healthy subjects ingested 10 mg of zolpidem with or without oral voriconazole pretreatment. The concentrations of zolpidem were measured in plasma up to 24 h and pharmacodynamic variables were monitored for 12 h. Voriconazole increased the peak plasma concentration of zolpidem by 1.23-fold [P < 0.05; 90% confidence interval (CI) 1.05, 1.45] and the area under the plasma zolpidem concentration-time curve by 1.48-fold (P < 0.001; 90% CI 1.29, 1.74). The time to peak plasma zolpidem concentration was unchanged by voriconazole but the half-life was prolonged from 3.2 to 4.1 h (P < 0.01; 95% CI on the difference 0.27, 1.45). The pharmacodynamics of zolpidem were unaffected by voriconazole. Voriconazole caused a moderate increase in exposure to zolpidem in healthy young subjects but no clear pharmacodynamic changes were observed between the groups.This publication has 18 references indexed in Scilit:
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