Effect of omeprazole on the steady‐state pharmacokinetics of voriconazole
- 17 November 2003
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 56 (s1), 56-61
- https://doi.org/10.1046/j.1365-2125.2003.02000.x
Abstract
Voriconazole, a novel triazole antifungal agent, is metabolized by the cytochrome P450 isoenzymes CYP2C19, CYP2C9, and to a lesser extent by CYP3A4. Omeprazole, a proton pump inhibitor used widely for the treatment of gastric and duodenal ulcers, is predominantly metabolized by CYP2C19 and CYP3A4. The aim of this study was to determine the effects of omeprazole on the steady-state pharmacokinetics of voriconazole. A secondary objective was to characterize the pharmacokinetic profile of an oral loading dose regimen of 400 mg twice-daily voriconazole on day 1. This was an open, randomized, placebo-controlled, two-way crossover study of 18 healthy male volunteers. Subjects received oral voriconazole (400 mg twice daily on day 1 followed by 200 mg twice daily on days 2-9 and a single 200-mg dose on day 10) with either omeprazole (40 mg once daily) or matched placebo for 10 days. There was a minimum 7-day washout between treatment periods. Mean Cmax and AUCtau of voriconazole were increased by 15%[90% confidence interval (CI) 5, 25] and 41% (90% CI 29, 55), respectively, with no effect on tmax during coadministration of omeprazole. Visual inspection of predose plasma concentrations (Cmin) indicated that steady-state plasma concentrations were achieved following the second loading dose. One subject withdrew from the study during the voriconazole + omeprazole treatment period because of treatment-related abnormal liver function test values. All other treatment-related adverse events resolved without intervention. Omeprazole had no clinically relevant effect on voriconazole exposure, suggesting that no voriconazole dosage adjustment is necessary for patients in whom omeprazole therapy is initiated. Administration of a 400-mg twice-daily oral loading dose regimen on day 1 resulted in steady-state plasma levels of voriconazole being achieved following the second loading dose.Keywords
This publication has 17 references indexed in Scilit:
- Pharmacokinetics and Safety of Voriconazole following Intravenous- to Oral-Dose Escalation RegimensAntimicrobial Agents and Chemotherapy, 2002
- Clinical Significance of the Cytochrome P450 2C19 Genetic PolymorphismClinical Pharmacokinetics, 2002
- Voriconazole: A second-generation triazoleDrugs of Today, 2001
- Current and Emerging Azole Antifungal AgentsClinical Microbiology Reviews, 1999
- Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin*Clinical Pharmacology & Therapeutics, 1997
- Pharmacokinetics, Metabolism and Interactions of Acid Pump InhibitorsClinical Pharmacokinetics, 1996
- [14] Assays of omeprazole metabolism as a substrate probe for human CYP isoformsMethods in enzymology, 1996
- Drug Interactions and the Cytochrome P450 SystemClinical Pharmacokinetics, 1995
- Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism.British Journal of Clinical Pharmacology, 1994
- The Clinical Importance of Drug Interactions with Antiulcer TherapyJournal of Clinical Gastroenterology, 1990