Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths
- 5 July 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 13 (8), 607-614
- https://doi.org/10.1038/nri3476
Abstract
In this Opinion, the authors provide their perspective on how the type 2 immune response may have evolved and how it functions to mediate both resistance and tolerance to tissue-destructive helminths. They propose that the damage induced during helminth migration and the subsequent need for tissue repair have been major factors in driving the evolution of the type 2 response. Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.Keywords
This publication has 93 references indexed in Scilit:
- Mechanisms of fibrosis: therapeutic translation for fibrotic diseaseNature Medicine, 2012
- An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infectionNature Medicine, 2012
- Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesisNature, 2011
- TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammationNature, 2011
- To B or not to B: B cells and the Th2-type immune response to helminthsTrends in Immunology, 2010
- IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responsesNature, 2010
- Nuocytes represent a new innate effector leukocyte that mediates type-2 immunityNature, 2010
- Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4-, and IFN-β-dependentMucosal Immunology, 2010
- Protective immune mechanisms in helminth infectionNature Reviews Immunology, 2007
- Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasitesNature Medicine, 2006