The physiological and clinical effects of progesterone inhibition with mifepristone (RU 486) in the second trimester
- 1 June 1990
- journal article
- clinical trial
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 97 (6), 487-492
- https://doi.org/10.1111/j.1471-0528.1990.tb02517.x
Abstract
Summary. A double-blind placebo-controlled trial was performed in 20 primigravidae to assess the physiological and clinical effects of oral mifepristone on myometrial contractility and sensitivity in the second trimester. Ten women received 600 mg of oral mifepristone and 10 women a placebo 24 h before abortion was induced in both groups, with extra-amniotic PGE2 instillation. Intrauterine pressure recordings demonstrated increased spontaneous uterine activity and increased sensitivity to PGE2 and ergometrine, but no change in oxytocin sensitivity after mifepristone treatment. There were no significant differences in PGE or PGF metabolite concentrations in peripheral maternal plasma over the 24-h study period after treatment between the mifepristone and placebo groups. The mean induction abortion interval in the mifepristone group was 512 (SD 321) min compared with 1128 (SD 606) min in the placebo group (P≤0.02). The mechanism whereby mifepristone provokes enhanced uterine contractility and sensitivity to prostaglandins, with a reduction in abortion times, does not appear to be through endogenous production of PGE or PGF.Keywords
This publication has 26 references indexed in Scilit:
- MIFEPRISTONE AND INDUCTION OF LABOUR IN SECOND HALF OF PREGNANCYThe Lancet, 1988
- The effect of the antiprogestin RU 486 on uterine contractility and sensitivity to prostaglandin and oxytocinBJOG: An International Journal of Obstetrics and Gynaecology, 1988
- MIFEPRISTONE (RU 486) AND SECOND-TRIMESTER TERMINATIONThe Lancet, 1987
- Progesterone inhibition in mid‐trimester termination of pregnancy: physiological and clinical effectsBJOG: An International Journal of Obstetrics and Gynaecology, 1987
- Myometrial activity in first trimester human pregnancy after Epostane therapy. Effect of intravenous oxytocinBJOG: An International Journal of Obstetrics and Gynaecology, 1985
- Progesterone receptor blockageContraception, 1985
- Endocrinology of human parturition: a reviewBJOG: An International Journal of Obstetrics and Gynaecology, 1984
- SINGLE EXTRA‐AMNIOTIC INJECTION OF PROSTAGLANDINS IN VISCOUS GEL TO INDUCE ABORTIONBJOG: An International Journal of Obstetrics and Gynaecology, 1976
- The Modulation of Progesterone Concentration in the Myometrium of the Pregnant Rat by Changes in Cytoplasmic “Receptor” Protein Activity1Endocrinology, 1973
- LABOUR: A DELAYED MENSTRUATION ?The Lancet, 1972